Perspective
A new publication by MSD in Organic Process Research & Development details the process development and large-scale manufacturing of the key Northern Fragment of Enlicitide Decanoate.
A new publication by MSD in Organic Process Research & Development details the process development and large-scale manufacturing of the key Northern Fragment of Enlicitide Decanoate.
The publication highlights how a series of innovative process chemistries, including selective allylation, one-pot peptide coupling, streamlined deprotection, and regioselective macrolactamization, enabled the production of over 150 kg with enhanced yield, purity, and efficiency.
We are proud to support this important program and co-author this paper. We are grateful for the opportunity to help enable a more efficient and sustainable manufacturing solution for this complex oral peptide. Our team remains committed to delivering high-quality, scalable solutions that accelerate the development of our partners’ innovative therapies and bring them to patients worldwide.
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