Unnatural Amino Acid

We are experts in synthesizing a wide variety of unnatural amino acids (UAA), including the most challenging structures, tailored to our customers’ specifications at all stages. We offer 2,500+ unnatural amino acid products with various types and scales.

Visit our UAA Catalog e-Shop here.

Leveraging the knowledge and synthetic expertise of our seasoned chemists, we also offer custom amino acid synthesis services from laboratory scale to production scale. We customized 12,000+ unnatural amino acids in last 5 years.

Experience Highlights

α-Me-amino acids:

• We utilize the natural amino acid Alanine to design α-Me-amino acid derivatives. This methodology can be extended to other natural amino acids, such as Leucine, Phenylalanine, etc.

N-Me-amino acids:

• We have developed a cyclization process that allows methylation to be achieved in just two steps.

PG series:

• All protecting strategies, including Boc, Fmoc, Cbz, Mtt, DDE, and IVDDE, can be implemented.

α- and β- construction series:

• We have developed enzyme catalyst techniques to construct selectable α- or β-site unnatural amino acids.

NCA series:

• We have developed a process to effectively control the quality of NCAs.

Samples of Unnatural Amino Acids

Case Study

• n=0,1,2…, m=1,2,3…
• Custom synthesis, from g to kg scale
• R1, R2, R3 can be different protecting groups upon your design
• Key building block for alternative route in cyclic peptide systhesis
• An alternative option for thioether macrocycles

• Commercial available in small quantity: 100 mg
• Commonly used for copper free click reaction
• Ideal building block for peptide fragment conjugation
• WuXi TIDES is capable of providing these analogs in 500+ grams scale with short timeline.