Peptide · Discovery
Conjugate
Peptide conjugation is a rapidly expanding field, offering a new modality for targeted drug delivery. This approach enhances efficacy and reduces side effects in cancer treatment. Our…
Peptide Conjugate Discovery
Peptide conjugation is a rapidly expanding field, offering a new modality for targeted drug delivery. This approach enhances efficacy and reduces side effects in cancer treatment. Our comprehensive peptide platform, combined with our small molecule chemistry capability, provides a one-stop solution for your peptide conjugate discovery projects.
We support various peptide conjugates, including but not limited to:
- Peptide-Toxin
- Peptide-Metal
- Peptide-GalNAc
- Peptide-PMO
- Peptide-Oligonucleotide
- Radionuclide Drug Conjugate (RDC)
Experience Highlights
- 2,000+ peptide drug conjugate projects delivered
- 350+ linkers synthesized
- 50+ payload modifications completed
- 80+ peptides, lipids, PEG linkers — readily available for conjugation
Samples of 350+ Linkers
Samples of 50+ Payload Modifications
Case Study: Peptide Drug Conjugation
We enabled seamless collaboration among SPPS, LPPS, purification, and analytical teams, all located at one site.
The project was completed 3-4 week faster compared with convension methods of separate manufacturing peptides and payloads.
Seamless collaboration with in-parallel activities among 4 workstreams
Swift sample transport and information sharing from upstream to downstream teams
Case Study: Radionuclide Drug Conjugates (RDC)
In this case study, we demonstrated a project in which the WuXi TIDES peptide teams successfully enabled a challenging RDC to IND filing in three months. Leveraging our extensive expertise and capabilities in peptide and small molecule chemistry, robust synthesis and manufacturing solutions were developed. Download Full Article
Seamless collaboration with in-parallel activities among 4 workstreams
Swift sample transport and information sharing from upstream to downstream teams
Peptide-Phosphorodiamidate Morpholino Oligomers (PMO)
Leveraging our peptide manufacturing from one site in Changzhou, China, WuXi TIDES can also produce peptide-PMO (PPMO) with streamlined process. PMO and PPMO development and manufacturing are supported by our in-house comprehensive analytical, project management, as well as CMC regulatory teams. To date, we have completed dozens of PMO projects including 10+ PPMO projects.
Peptide Oligonucleotide Conjugate (POC)
Our Unique ‘One-Stop’ POC Synthesis Services
- ‘One-stop’ POC synthesis with 10+ years of experience in both oligonucleotide and peptide
- 80+ peptides, lipids, PEG linkers — readily available for conjugation chemistry
- ‘Custom-tailored’ design of linker / conjugation chemistry including dual conjugation chemistry
Learn more about our Oligonucleotide platform.
Related Resources
Webinar: Challenges and Opportunities in Peptide Drug Conjugates (PDCs)
Empowering Highly Potent Peptide Drug Conjugate Scale-up with Flow Chemistry
Case Study: PDC Drug R&D and Manufacturing in 9 Months
Webinar: Challenges and Opportunities in Peptide Drug Conjugates (PDCs)
Empowering Highly Potent Peptide Drug Conjugate Scale-up with Flow Chemistry
Case Study: PDC Drug R&D and Manufacturing in 9 Months
Why WuXi TIDES
What this platform adds
Scalability
From discovery to commercialisation entirely within WuXi TIDES, with readily available large R&D and manufacturing capacity.
Conjugation Chemistry
Seamless collaboration across the oligonucleotide, peptide and small molecule teams — the conjugates nobody else wants to touch.
New Technology
Biocatalysis for gRNA synthesis, thin film evaporation, reactor-in-series with PAT, continuous flow chromatography, TFF.
Global Quality Standard
One quality system across every site, approved by the major regulatory agencies around the world.
Comprehensive Analytical
Method development and validation, IPC and release testing, characterisation and stability under one roof.
Integrated CMC
API and formulation development, manufacturing, analytical, dossier preparation and clinical supply as a single programme.
Meeting global quality standards
Inspection record
How can we help?
Our TIDES drug experts stand ready.
Tell us where your molecule is today — discovery, CMC, or commercial supply — and we will map the fastest credible route to patients.
Small molecule projects? WuXi STA