Conjugate

Oligonucleotide conjugates open up opportunities to deliver the oligonucleotide to a specific cell or tissue and to fine-tune the ‘drug-like’ properties. However, the complexity of conjugation chemistry poses great challenges for drug innovators and manufacturers.

WuXi TIDES is well positioned to provide a one-stop solution for complex oligonucleotide-conjugate drugs from discovery to development and commercial manufacturing, with our strong capabilities in both oligonucleotide, peptide and small molecules including ligand, toxin, linker, lipid, PEG etc.

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Why choose WuXi TIDES?

• Comprehensive: Extensive experience in various modalities
• Diversity: Large variety of linkers / conjugation strategies
• Flexibility: Custom-tailored solution according to your application

Type of Oligonucleotide Conjugates

• PPMO
• GalNAc-oligonucleotide
• Lipid-oligonucleotide
• Peptide-oligonucleotide (POC)
• 'Drug'-oligonucleotide
• Dye-labelled oligonucleotide

Linker Chemistry

• Amide Coupling
• Thiol-maleimide addition
• Click chemistry (CuAAC | SPAAC)
• Broad selection of spacers
• Custom-tailored linkers

Topology

• 3'- or 5'-conjugation
• Internal conjugation
• Base/backbone conjugation
• Complex dual conjugation: (3', 5'- / 3', 3'- / 5', 5'-)
• Multi-valency (Mono- / di- / tri- / tetra)

Type of Oligonucleotide Conjugates

• PPMO
• GalNAc-oligonucleotide
• Lipid-oligonucleotide
• Peptide-oligonucleotide (POC)
• 'Drug'-oligonucleotide
• Dye-labelled oligonucleotide

Linker Chemistry

• Amide Coupling
• Thiol-maleimide addition
• Click chemistry (CuAAC | SPAAC)
• Broad selection of spacers
• Custom-tailored linkers

Topology

• 3'- or 5'-conjugation
• Internal conjugation
• Base/backbone conjugation
• Complex dual conjugation: (3', 5'- / 3', 3'- / 5', 5'-)
• Multi-valency (Mono- / di- / tri- / tetra)

Lipid

Peptide

Carbohydrate

Fluorescent-dye

PEG